Product substitution can mitigate supply chain disruptions. However, it may not be very effective without multiple sourcing. In this paper, we consider a supply chain with two downward substitutable products. The products can be ordered from an unreliable supplier or a reliable but more...

Several design guidelines and flexibility indices have been developed in the literature to inform the design of flexible production networks. In this paper, we propose additional flexibility design guidelines for unbalanced networks, where the numbers of plants and products are not equal, by...

In this paper, we consider the discrete multiperiod newsvendor dynamic inventory control problem where customers follow a simple satisfaction-based demand process, where their probability of demand depends on whether their demand was satised the last time they demanded a product, and observe the...

We introduce an optimization-based production planning tool for the biotechnology industry. The industry’s planning problem is unusually challenging because the entire production process is regulated by multiple external agencies – such as the US Food and Drug Administration – representing...