We develop a framework for automated optimization of stochastic simulation models using Response Surface Methodology … function is very expensive or time-consuming. Response Surface Methodology is frequently used for the optimization of … need to interfere in the optimization process. In our framework for automated optimization we describe all choices that …

can be estimated by optimization of the goodness-of-fit. We compared the efficiency and accuracy of the Response Surface … Methodology and the Nelder and Mead Simplex Method for optimization of microsimulation models. To this end, we tested several … respect to accuracy, Response Surface Methodology performed better in case of optimization of the microsimulation model …