The joint effect of several variables is a prevailing statistical concept in biology. The public health importance of developing methods to better assess joint effects is evident when studying gene combinations that function together to produce a disease phenotype, or biomarker pairs that...

Many research areas require multiple outcomes. For example, neuropsychological hypotheses may not be testable using a single measure. Similarly, genetic researchers frequently examine multiple markers across the genome. Examining multiple hypotheses requires the use of multiple testing...

Statistical approaches used for gene mapping can be divided into two types: linkage and association analysis. This dissertation work addresses statistical methods in both areas.In the area of linkage analysis, I consider the problem of QTL (Quantitative Trait Locus) linkage analysis. Linkage...