Objective: To estimate the economic impact of using low dose polyethyene glycol 3350 (PEG 3350) plus electrolytes (PEG+E) compared with lactulose in the treatment of idiopathic constipation in ambulant patients. Design and perspective: This was a decision analytic modelling study performed from...

Objective: To assess the economic impact of adding granulocyte colony-stimulating factor (G-CSF) to amphotericin B to treat a presumed deep-seated fungal infection in neutropenic patients. This study was conducted from the perspective of the National Health Service (NHS) hospital sector. Design:...

Objective: To estimate the economic impact of using tibolone 2.5mg compared with 17beta-estradiol 2mg/norethisterone acetate 1mg (E2/NETA) in postmenopausal women with climacteric symptoms. Design and setting: This was a modelling study performed from the perspective of the UK's National Health...

Objective: The objective of this study was to estimate the annual resource use and corresponding costs (at 1996/97 prices) to the UK's National Health Service (NHS) arising from the management of chronic obstructive pulmonary disease (COPD). Design and Setting: A subgroup analysis was performed...

Objective: This study estimated the cost to UK society of an annual cohort of newly diagnosed patients with schizophrenia over the first 5 years following diagnosis, using an incidence-based cost-of-illness framework. Design and setting: A discrete event model of the course of schizophrenia was...

Objective: To determine the effect of age, disease severity and compliance on the annual primary-care cost of managing patients with asthma initially on British Thoracic Society British Guidelines on Asthma Management (BGAM) treatment steps 2/3 over 5 years. Design and setting: A modelling study...

Objective: To measure health-related quality of life (HR-QOL) among a sample of men with erectile dysfunction (ED) in the UK. Study population and methods: A structured questionnaire was mailed to a sample of 5000 men in the UK with ED. The questionnaire included the International Index of...

An extensive MEDLINE search revealed a paucity of studies assessing economic outcomes associated with managing emphysema. Consequently, we estimated the annual levels of National Health Service (NHS) resource use and corresponding costs (at 1995/96 prices), by performing a subgroup analysis of a...

Objectives: To model the economic impact of introducing an occupational vaccination programme for influenza with an inactivated influenza subunit vaccine (Influvac(R)) in the UK. Design and setting: Using published sources, a decision tree was constructed which modelled the costs and benefits of...

Objective: To estimate the relative cost effectiveness for women aged =30 years, starting long-term hormonal contraception with either levonorgestrel intrauterine system (Mirena(R)), etonogestrel subdermal implant (Implanon(R)) or medroxyprogesterone acetate injection (Depo-Provera(R)). Design...