In the first part of the dissertation, we derive two methods for responders analysis in longitudinal data with random missing data. Often a binary variable is generated by dichotomizing an underlying continuous variable measured at a specific point in time according to a prespecified threshold...

In many clinical studies, researchers are interested in theeffects of a set of prognostic factors on the hazard of death from a specific disease even though patients may die from other competing causes. Often the time to relapse is right-censored for some individuals due to incomplete follow-up....