As I document using evidence from a journal data repository that I manage, the datasets used in empirical work are getting larger. When we use very large datasets, it can be dangerous to rely on standard methods for statistical inference. In addition, we need to worry about computational issues....

Inference using difference-in-differences with clustered data requires care. Previous research has shown that, when there are few treated clusters, t-tests based on cluster-robust variance estimators (CRVEs) severely overreject, and different variants of the wild cluster bootstrap can either...