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Global relations between RNA sequences and secondary structures are understood as mappings from sequence space into shape space. These mappings are investigated by exhaustive folding of all GC and AU sequences with chain lengths up to 30. The technique of tried is used for economic data storage...
Persistent link: https://www.econbiz.de/10005790884
Random graph theory is used to model relationships between sequences and secondary structure of RNA molecules. Sequences folding into identical structures form neutral networks which percolate sequence space if the fraction of neutral nearest neighbors exceeds a threshold value. The networks of...
Persistent link: https://www.econbiz.de/10005739980
Shapes of biological macromolecules---RNA, DNA, and proteins---can be represented by abstract algebraic structures provided as suitably coarse resolution is chosen. These abstract structures, for instance partially ordered sets and permutation groups, can be used for deriving new metric...
Persistent link: https://www.econbiz.de/10005790646
A mapping in random structures is defined on the vertices of a generalized hypercube {\cal Q}^n_\alpha. A random structure consists of (i) a random contact graph and (ii) a family of relations inposed on adjacent vertices of the random contact graph. The vertex set of a random contact graph is...
Persistent link: https://www.econbiz.de/10005790731
We view the folding of RNA-sequences as a map that assigns a pattern of base pairings to each sequence, known as secondary structure. These preimages can be constructed as random graphs (i.e., the neutral networks associated to the structures). <p> By interpreting the secondary structure as...</p>
Persistent link: https://www.econbiz.de/10005790747
Folding of RNA sequences into secondary structures is viewed as a map that assigns a uniquely defined base pairing pattern to every sequence. This mapping is non-invertible since many sequences fold into the same (secondary) structure or shape. The preimages of the map, called neutral networks,...
Persistent link: https://www.econbiz.de/10005790801
Folding of RNA sequences into secondary structures is viewed as a map that assigns a uniquely defined base pairing pattern to every sequence. The mapping is non-invertible since many sequences fold into the same minimum free energy (secondary) structure or shape. The preimages of this map,...
Persistent link: https://www.econbiz.de/10005790908