The determination of toxicokinetic parameters is an essential component in the risk assessment of potential harmful chemicals. It’s a first step to analyse the processes which are involved in the development of DNA adducts and might therefore lead to the development of cancer. The complete...

The determination of toxicokinetic parameters is an essential component in the risk assessment of potential harmful chemicals. It is a key step to analyse the processes involved in the formation of DNA adducts which are connected with the development of chemical-induced cancer. A general problem...

The present method allows to detect outlying observations in data which may be described by a deterministic function plus a stochastic component. This type of functional relationship often occurs in experimental data, in toxicological research, for instance. The Hampel identifier, an outlier...

A basic part in the risk assessment of potential carcinogens is the determination of toxicokinetic parameters. The partition of the xenobiotic in the body of experimental animals is a first step of the biochemical pathway of the formation of DNA adducts which might lead to the development of...

A basic step in the risk assessment of potential carcinogens is the determination of toxicokinetic parameters. The present approach is part of a strategy to determine the processes of uptake, elimination, and metabolism of the gas ethylene, an important industrial chemical, which is classified...

A basic part in the risk assessment of potential carcinogens is the determination of toxicokinetic parameters. The partition of the xenobiotic in the body of experimental animals is a first step of the biochemical pathway of the formation of DNA adducts which might lead to the development of...

N-Acetyltransferase 2 (NAT2) genotyping may result in a considerable percentage in several ambiguous allele combinations. PHASE 2.1 is a statistical program which is designed to estimate the probability of different allele combinations. We have investigated haplotypes of 2088 subjects genotyped...

The issue of suitable similarity measures for a particular kind of genetic data - so called SNP data - arises, e.g., from the GENICA (The Interdisciplinary Study Group on Gene Environmental Interactions and Breast Cancer in Germany) case-control study of sporadic breast cancer. The GENICA study...

The issue of suitable similarity measures for a particular kind of genetic data – so called SNP data – arises from the GENICA (Interdisciplinary Study Group on Gene Environment Interaction and Breast Cancer in Germany) case-control study of sporadic breast cancer. The GENICA study aims to...

Potentially adverse human and environmental effects due to hormone mimicry of environmental estrogens are a matter of current concern. Environmental estrogens belong to the socalled endocrine active compounds (EAC) and may alter signalling processes of the endocrine system leading to a broad...