Narrow search
Showing 1 - 7 of 7
Cover Image
Loss-Based Cross-Validated Deletion/Substitution/Addition Algorithms in Estimation
Sinisi, Sandra; Laan, Mark van der - Berkeley Electronic Press - 2004
In van der Laan and Dudoit (2003) we propose and theoretically study a unified loss function based statistical methodology, which provides a road map for estimation and performance assessment. Given a parameter of interest which can be described as the minimizer of the population mean of a loss...
Persistent link: https://www.econbiz.de/10005751450
Cover Image
Loss-Based Estimation with Cross-Validation: Applications to Microarray Data Analysis and Motif Finding
Dudoit, Sandrine; Laan, Mark van der; Keles, Sunduz; … - Berkeley Electronic Press - 2004
Current statistical inference problems in genomic data analysis involve parameter estimation for high-dimensional multivariate distributions, with typically unknown and intricate correlation patterns among variables. Addressing these inference questions satisfactorily requires: (i) an intensive...
Persistent link: https://www.econbiz.de/10005459073
Cover Image
Deletion/Substitution/Addition Algorithm in Learning with Applications in Genomics
Sinisi, Sandra; Laan, Mark van der - In: Statistical Applications in Genetics and Molecular Biology 3 (2007) 1, pp. 18-18
van der Laan and Dudoit (2003) provide a road map for estimation and performance assessment where a parameter of interest is defined as the risk minimizer for a suitable loss function and candidate estimators are generated using a loss function. After briefly reviewing this approach, this...
Persistent link: https://www.econbiz.de/10005585079
Cover Image
Multiple Testing and Data Adaptive Regression: An Application to HIV-1 Sequence Data
Birkner, Merrill; Sinisi, Sandra; Laan, Mark van der - Berkeley Electronic Press - 2004
Analysis of viral strand sequence data and viral replication capacity could potentially lead to biological insights regarding the replication ability of HIV-1. Determining specific target codons on the viral strand will facilitate the manufacturing of target specific antiretrovirals. Various...
Persistent link: https://www.econbiz.de/10005246353
Cover Image
Multiple Testing and Data Adaptive Regression: An Application to HIV-1 Sequence Data.
Birkner, Merrill; Sinisi, Sandra; Laan, Mark van der - In: Statistical Applications in Genetics and Molecular Biology 4 (2007) 1, pp. 8-8
Analysis of viral strand sequence data and viral replication capacity could potentially lead to biological insights regarding the replication ability of HIV-1. Determining specific target codons on the viral strand will facilitate the manufacturing of target-specific antiretrovirals. Various...
Persistent link: https://www.econbiz.de/10005246474
Cover Image
Deletion/Substitution/Addition Algorithm in Learning with Applications in Genomics
Sinisi, Sandra; Laan, Mark van der - In: Statistical Applications in Genetics and Molecular Biology 3 (2009) 1, pp. 18-18
van der Laan and Dudoit (2003) provide a road map for estimation and performance assessment where a parameter of interest is defined as the risk minimizer for a suitable loss function and candidate estimators are generated using a loss function. After briefly reviewing this approach, this...
Persistent link: https://www.econbiz.de/10005046582
Cover Image
Multiple Testing and Data Adaptive Regression: An Application to HIV-1 Sequence Data.
Birkner, Merrill; Sinisi, Sandra; Laan, Mark van der - In: Statistical Applications in Genetics and Molecular Biology 4 (2009) 1, pp. 8-8
Analysis of viral strand sequence data and viral replication capacity could potentially lead to biological insights regarding the replication ability of HIV-1. Determining specific target codons on the viral strand will facilitate the manufacturing of target-specific antiretrovirals. Various...
Persistent link: https://www.econbiz.de/10005046606