Continuum and compartmental models are presented as alternative descriptions of the electrical behaviour of a dendrite. The one-dimensional continuum model provides a reference against which the accuracy of compartmental models may be assessed. Traditional compartmental models are shown to be...

Purpose: Observational studies may provide important information on the long-term effects of treatments for epilepsy, but systematic reviews of observational studies may be more prone to heterogeneity and biases. These issues were investigated in a systematic review of non-randomised add-on...

In this work we develop an approach to extracting information from neural spike trains. Using the expectation-maximization (EM) algorithm, interspike interval data from experiments and simulations are fitted by mixtures of distributions, including Gamma, inverse Gaussian, log-normal, and the...

We describe a quantitative and comparative review of a selection of European birthweight standards for gestational age for singletons, to enable appropriate choices to be made for clinical and research use. Differences between median values at term across standards in 10 regions and...

Evoked potentials are usually evaluated subjectively, by visual inspection, and considerable differences between interpretations can occur. Objective, automated methods are normally based on calculating one (or more) parameters from the data, but only some of these techniques can provide...

Muscle models are an important tool in the development of newrehabilitation and diagnostic techniques. Many models have been proposed in the past, but little work has been done on comparing the performance of models. In this paper, seven models that describe the isometric force response to pulse...

Decision trees are hierarchical, sequential classification structures that recursively partition the set of observations (data) and are used to represent rules underlying the observations. This article describes the development of TreeWorks, a tool that enhances existing decision tree theory and...

This paper describes the development and application of a simulation tool for modelling patient choice in healthcare systems. Patient choice is already offered in the English National Health Service (NHS) and proposed reforms will propel choice to the forefront of NHS re-structuring by offering...

We consider the estimation of the location of the pole and memory parameter, λ0 and α respectively, of covariance stationary linear processes whose spectral density function f(λ) satisfies f(λ) ∼ C|λ − λ0|−α in a neighbourhood of λ0. We define a consistent estimator of λ0 and...

Consumers are often confronted with choices between options that vary in their short and long term benefit, or what we call immediate and delayed utility. This paper describes the marketing implications of what economists and psychologists have learned about how consumers make these choices. The...