Mathematical modeling is a key component of various disciplines in science andengineering. A mathematical model which represents important behavior of a realsystem can be used as a substitute for the real process for many analysis and synthesistasks. The performance of model based techniques,...

The stability of sexual risk behavior over time is a common assumption in models of HIV transmission. In this thesis I show that this assumption does not hold in a population of gay men at risk of HIV infection and that the violation of this assumption has major implications for our...

Considers the analysis of longitudinal data by means of the autogressive or simplex model. The finding by D. Rogosa and J. B. Willett that the quasi-Markov simplex model fits a linear growth curve covariance structure is investigated. Under various circumstances the quasi-Markov simplex model is...

The extent to which economic evaluations of public health programs in Ontario are conducted and used by decision makers is currently very limited. This thesis supports public health decision-making through applied and methodological work. The applied work demonstrates different methods to...