This dissertation presents two essays on Markov-Switching dynamic stochastic general equilibrium models. The first essay is "Perturbation Methods for Markov-Switching Models," which is co-authored with Juan Rubio-Ramirez, Dan Waggoner, and Tao Zha. This essay develops an perturbation-based...

The prediction of future temperature increases depends critically on the projections of future greenhouse gas emissions. Yet there is a vigorous debate about how these projections should be undertaken and how reasonable is the approach of the Special Report on Emissions Scenarios (SRES)...

The population dynamics underlying the diffusion of ideas hold many qualitative similarities to those involved in the spread of infections. In spite of much suggestive evidence this analogy is hardly ever quantified in useful ways. The standard benefit of modeling epidemics is the ability to...

Background: Although an important source of treatment for fevers, little is known about the structure of the retail sector in Africa with regard to antimalarial drugs. This study aimed to assess the range, costs, sources and registration of antimalarial drugs in the Kenyan retail sector.Methods:...

Mit der Gründung der WTO am 1.1.1995 trat das TRIPS-Übereinkommen in Kraft. Es verpflichtet alle WTO Mitglieder zur Umsetzung von Rechten zum Schutze des geistigen Eigentums, welche dem Niveau industrialisierter Staaten nahezu entsprechen. Die Stärkung internationaler Immaterialgüterrechte...

Harm reduction interventions to reduce blood-borne disease incidence among injection drug users (IDUs). A common strategy to estimate the long-term impact of such interventions is to examine short-term incidence changes within a specific group of individuals exposed to the intervention. Such...

The extent to which economic evaluations of public health programs in Ontario are conducted and used by decision makers is currently very limited. This thesis supports public health decision-making through applied and methodological work. The applied work demonstrates different methods to...

We present a hypothetical model of the change in economic costs and health benefits to society that result from nosocomial infection-control programmes. We include values for costs incurred by the hospital sector, community health services and the private costs to patients. We value health...