Koca, Yesim; Martagan, Tugce; Adan, Ivo; Maillart, Lisa; … - 2022
Problem definition: Bleed-feed is a novel technology that allows biomanufacturers to skip intermediary bioreactor setups. However, the specific time at which bleed-feed is performed is critical for success. The process is stringently regulated, and its implementation involves unique trade-offs...