We consider an extended version of a model proposed by Ledford and Tawn [Ledford, A.W., Tawn, J.A., 1997. Modelling dependence within joint tail regions. J. R. Stat. Soc. 59 (2), 475-499] for the joint tail distribution of a bivariate random vector, which essentially assumes an asymptotic power...

We propose a nonparametric Bayesian local clustering (NoB-LoC) approach for heterogeneous data. NoB-LoC implements inference for nested clusters as posterior inference under a Bayesian model. Using protein expression data as an example, the NoB-LoC model defines a protein (column) cluster as a...

Histone modifications (HMs) are an important post-translational feature. Different types of HMs are believed to co-exist and co-regulate biological processes such as gene expression and, therefore, are intrinsically dependent on each other. We develop inference for this complex biological...

Die Tagung des Jungen Forums der ARL vom 6. bis 8. Juni 2012 in Hannover setzte sich mit dem Leitgedanken "Raumentwicklung 3.0 - Gemeinsam die Zukunft der räumlichen Planung gestalten" auseinander. Ziel war es, Perspektiven für die Zukunft der räumlichen Planung aufzuzeigen. Der Hintergrund...

High-throughput functional proteomic technologies provide a way to quantify the expression of proteins of interest. Statistical inference centers on identifying the activation state of proteins and their patterns of molecular interaction formalized as dependence structure. Inference on...

We consider inference for functional proteomics experiments that record protein activation over time following perturbation under different dose levels of several drugs. The main inference goal is the dependence structure of the selected proteins. A critical challenge is the lack of sufficient...