Optimization of an agent-based simulation (ABS) bears specific challenges. It is demonstrated in this paper that mainstream simulation-based optimization (SBO) approaches often do not perform well in such a setting, sometimes hardly outperforming a mere random search. Two new algorithms for SBO...

In the last years, customer centricity has turned out to be a promising paradigm for maximizing corporate value by increasing value contributions from customers. In this context, the discipline of revenue management provides plenty of methods to optimize (predominantly short-term) cash-inflows...

This paper deals with the generalized resource-constrained project scheduling problem (GRCPSP) which extends the well-known resource-constrained project scheduling problem (RCPSP) by considering job specific release and due dates, non-negative minimum start-to-start time lags as well as...

Methods used by CEAs of oral non-disease-altering OA treatments have evolved in response to changing treatments with different safety profiles and efficacies as well as technical advances in the application of decision science to health care. </AbstractSection> Copyright Springer International Publishing...

The model estimated that duloxetine was potentially cost effective in the base-case population and more cost effective for subgroups over 65 years or at high risk of NSAID-related AEs. In sensitivity analysis, duloxetine dominated all strong opioids in nearly all scenarios. </AbstractSection> Copyright Springer...

This paper deals with the generalized resource-constrained project scheduling problem (GRCPSP) which extends the well-known resource-constrained project scheduling problem (RCPSP) by considering job specific release and due dates, non-negative minimum start-to-start time lags as well as...

In this paper, we analyse a service provider’s mixed bundling problem for services such as sporting events or holiday packages. Pursuing the objective of maximising total revenue, the service provider has to determine static prices for each single product at the beginning of the selling...