Current technologies generate a huge number of single nucleotide polymorphism (SNP) genotype measurements in case-control studies. The resulting multiple testing problem can be ameliorated by considering candidate gene regions. The <Emphasis Type="Bold">minPtest R package provides the first widely accessible...</emphasis>

The bootstrap is a tool that allows for efficient evaluation of prediction performance of statistical techniques without having to set aside data for validation. This is especially important for high-dimensional data, e.g., arising from microarrays, because there the number of observations is...

In many settings with possibly non-linear influence of covariates, such as in the present application with children's respiratory health data, generalized additive models are an attractive choice. Although techniques for fitting these have been extensively investigated, there are fewer results...

Modern techniques for fitting generalized additive models mostly rely on basis expansions of covariates using a large number of basis functions and penalized estimation of parameters. For example, a mixed model approach is used to fit a model for children's lung function that allows for...

We develop an algorithm that incorporates network information into regression settings. It simultaneously estimates the covariate coefficients and the signs of the network connections (i.e. whether the connections are of an activating or of a repressing type). For the coefficient estimation...

Rating scales as predictors in regression models are typically treated as metrically scaled variables or, alternatively, are coded in dummy variables. The first approach implies a scale level that is not justified, the latter approach results in a large number of parameters to be estimated....