This paper explores challenges and difficulties faced by small countries in developing their public research systems (PRS). It compares Hungary (population around 10 million), Iceland (population around 300,000) and Ireland (population around 3.5 million) to identify national approaches to...

Objectives To describe the process of priority setting for two orphan drugs - Cerezyme and Fabrazyme - in Canada, Australia and Israel, in order to understand and improve the process based on stakeholder perspectives.Methods We conducted qualitative case studies of how three independent drug...

To describe stakeholder involvement in the priority setting and appeals processes across five drug reimbursement recommendation committees.