The major objective of this paper is to study the fault tolerance of gene networks. For single gene knockouts we investigate the disturbance of the communication abilities of gene networks globally. For our study we use directed scale-free networks resembling important properties of gene...

A multi-item make-to-order production system in a stochastic environment is analyzed. Assuming a common cycle production approach, the impact of safety stock, cycle time, demand, processing time and setup time on service-level and total relevant cost (holding, setup and backorder cost) is...

A multi-item capacitated make-to-order production system with considerable demand fluctuations is discussed. The relationship between the available capacity and the inventory needed to meet customer requirements with a pre-defined service level is modeled. Furthermore, the total cost for both...

In the context of a single machine, multi-item, continuous-time lot sizing and scheduling problem with a production rate alternating between the two values zero and full production rate, this paper identifies classes of equivalent problem instances which differ from one another in the way in...

In this paper a model for evaluating the influence of utilization, WIP, FGI, service level and production lead time on EVA (economic value added) is developed in order to link the available logistical key figures with a market perspective and discuss their influence on company value. The...

In this paper the influence of different dispatching rules on the average production lead time is investigated. Two theorems based on covariance between processing time and production lead time are formulated and proved theoretically. Theorem 1 links the average production lead time to the...