Costs of screening a series of 18, 152 newborn males for Duchenne muscular dystrophy (DMD) in Canada were evaluated. The final aim of neonatal screening for DMD is the avoidance of additional cases in the families identified. Total costs to avoid one case of DMD were estimated at Cdn. $172,000,...

For a smoothing spline or general penalized spline model, the smoothing parameter can be estimated using residual maximum likelihood (REML) methods by expressing the spline in the form of a mixed model. The possibility of bimodality in the profile log-likelihood function for the smoothing...

The investment problem in natural gas transmission in a static sense as analyzed by Chenery [Chenery, H. B. 1949. Engineering production functions. Quart. J. Econ. 63(November) 507-531.] and Lehn [Lehn, H. C. 1943. An analysis of gaspipeline economics. Am. Soc. Mech. Engrs. Trans. (July)...

In this paper, a dynamic continuous time model of the firm, encompassing operations and investments, is formulated as an optimal control problem in an activity analysis context. In the model, the objective of the firm is to maximize, subject to various constraints, the discounted value of...