This paper investigates the use of Design of Experiments in observational studies in order to select informative observations and features for classification. D-optimal plans are searched for in existing data and based on these plans the variables most relevant for classification are determined....

Suppose that a target function is monotonic, namely weakly increasing, and an original estimate of this target function is available, which is not weakly increasing. Many common estimation methods used in statistics produce such estimates. We show that these estimates can always be improved with...