Knowledge-based biomedical data science involves the design and implementation of computer systems that act as if they knew about biomedicine. Such systems depend on formally represented knowledge in computer systems, often in the form of knowledge graphs. Here we survey recent progress in...

General introduction -- Small firms and innovation -- Biotechnology and small firms -- The Brazilian policy for biotechnology -- The Brazilian institutional framework in biotechnology -- Small biotechnology firms in Brazil -- University and small biotechnology firms in Brazil -- SBFs linkages...