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In the midst of epidemics such as COVID-19, therapeutic candidates are unlikely to be able to complete the usual multiyear clinical trial and regulatory approval process within the course of an outbreak. We apply a Bayesian adaptive patient-centered model—which minimizes the expected harm of...
Persistent link: https://www.econbiz.de/10012833747
Comparing median outcomes to gauge treatment effectiveness is widespread practice in clinical and other investigations. While common, such difference-in-median characterizations of effectiveness are but one way to summarize how outcome distributions compare. This paper explores properties of...
Persistent link: https://www.econbiz.de/10013221966
Background: The COVID-19 or Coronavirus has impacted the world in an unprecedented way. More than 200 countries have been affected because of this novel coronavirus. Global public health, economy and society have all faced near breakdown. There is a surge for identifying vaccine or repurposing...
Persistent link: https://www.econbiz.de/10013236876
Persistent link: https://www.econbiz.de/10012664701
In the midst of epidemics such as COVID-19, therapeutic candidates are unlikely to be able to complete the usual multiyear clinical trial and regulatory approval process within the course of an outbreak. We apply a Bayesian adaptive patient-centered model--which minimizes the expected harm of...
Persistent link: https://www.econbiz.de/10012481758
Comparing median outcomes to gauge treatment effectiveness is widespread practice in clinical and other investigations. While common, such difference-in-median characterizations of effectiveness are but one way to summarize how outcome distributions compare. This paper explores properties of...
Persistent link: https://www.econbiz.de/10012482114
Persistent link: https://www.econbiz.de/10012237428
predict a hospital load and mortality, neither in Belgium nor in Sweden. On the contrary, Lock down (Belgium) or Shut down … generating a hospital load compatible with the capacity of the health system are not true. These assumptions take the models … asymptote, we assume an overload of hospital capacity and excess mortality …
Persistent link: https://www.econbiz.de/10014097809
Persistent link: https://www.econbiz.de/10013542953
providers. In this research, we study whether hospital IT improved patient mortality rates by accelerating the rate at which … counties with greater hospital IT capabilities exhibit fewer COVID-19 deaths. Consistent with the learning effect hypothesis … COVID-19 patients. We posit that hospital IT and clinical trials help hospitals achieve better health outcomes in the long …
Persistent link: https://www.econbiz.de/10013306695