Objective: To contain costs, the US Department of Defense instituted a mandated statin formulary conversion program, designating cerivastatin and simvastatin as the `preferred statins'. This study examines the effectiveness, safety, and statin cost effectiveness following conversion to...

Objective: To determine 1. whether influenza vaccination in the elderly is cost effective or cost saving compared with a non-intervention strategy and 2. whether it is worth framing a vaccination policy for this population. Background: Influenza causes substantial morbidity and mortality in...

Objective: To analyse the direct medical costs and effectiveness of vaccinating adults aged between 18 and 64 years and elderly persons =65 years of age with the 23-valent pneumococcal polysaccharide vaccine. Design and setting: This was a decision-analytic modelling study from the societal...

The use of modelling in economic evaluation is widespread, and it most often involves synthesising data from a number of sources. However, even when economic evaluations are conducted alongside clinical trials, some form of modelling is usually essential. The aim of this article is to review the...

Objective: To assess the cost effectiveness (net costs per life year gained) of pneumococcal vaccination of elderly individuals aged 65 years and over in The Netherlands. Design and setting: A pharmacoeconomic analysis was conducted from the healthcare perspective in The Netherlands. The gender-...

Objective: To evaluate the cost effectiveness of gemcitabine in the treatment of nonsmall cell lung cancer (NSCLC). Methods: Gemcitabine was compared with best supportive care and gemcitabine/cisplatin was compared with three standard chemotherapies and four other novel chemotherapy...

Objective: To examine the economic impact of a new implantable contraceptive, Implanon(R), in comparison with other available contraceptive methods. Design: This was a modelling study using cost data derived from national published sources and effectiveness data from either controlled clinical...

Cytomegalovirus (CMV) disease, an opportunistic complication in patients with AIDS, causes substantial morbidity and has high treatment costs. Although prevention of this disease is highly desirable, incremental cost-effectiveness estimates for proposed prophylactic strategies in the era prior...

Objective: to analyse the economic benefits, in comparison with placebo, of the secondary prevention of ischaemic stroke and myocardial infarction (MI) with lysine acetylsalicylate (Kardegic(R)) in patients with a history of ischaemic stroke, MI or stable and unstable angina pectoris. Design and...