Under a random effects logistic regression model, asymptotic and exact test procedures in closed form for testing equality of binary responses are developed for comparing three treatments in a three-period crossover trial. Monte Carlo simulation is employed to evaluate the performance of these...

The proportion ratio (PR) of patient response is one of the most commonly used indices for measuring the relative treatment effect in a randomized clinical trial (RCT). Assuming a random effect multiplicative risk model, we develop two point estimators and three interval estimators in closed...