Testing non-inferiority in active-controlled clinical trials examines whether a new procedure is, to a pre-specified amount, no worse than an existing procedure. To assess non-inferiority between two procedures using clustered matched-pair binary data, two new statistical tests are...

In diagnostic methods evaluation, analysts commonly focus on the relative size of the treatment difference (ratio of marginal probabilities) between a new and an existing procedures. To assess non-inferiority (a new procedure is, to a pre-specified amount, no worse than an existing procedure)...