scrambling bootstrap method to give a nonparametric estimate of the variance of our test statistic under the null hypothesis …

A method is presented for automated preparation of bootstrap data samples and their presentation to NONMEM for use in … numbers of subjects. The bootstrap sampling procedure involves the use of an MS-DOS batch file and a script file for use with …. The method can easily be adapted to bootstrap sampling requirements in other biomedical modelling applications. (C) 1999 …