Introduction -- PRM and types of project uncertainties -- Overview of DMDU methodologies -- Project complexity concept -- Decision-making framework -- Selection of project options in situations of deep uncertainty -- Development of project schedule and cost contingencies in complex projects --...

In pharmaceutical R&D, decision makers face a large portion of uncertainty in portfolio decisions. Existing optimization tools are mostly based on expected values, ignoring uncertainty, and most often deliver a single, "best" selection of projects. A decision tree approach can aid decision...