The determination of toxicokinetic parameters is an essential component in the risk assessment of potential harmful chemicals. It’s a first step to analyse the processes which are involved in the development of DNA adducts and might therefore lead to the development of cancer. The complete...

The correlated Weibull regression model for the analysis of correlated binary data is presented. This regression model is based on Bonney’s disposition model for the regression analysis of correlated binary outcomes. Parameter estimation was done through the maximum likelihood method. The...

Microarrays are part of a new class of biotechnologies which allow the monitoring of expression levels of thousands of genes simultaneously. In microarray data analysis, the comparison of gene-expression profiles with respect to different conditions and the selection of biologically interesting...

Microarrays are part of a new class of biotechnologies which allow the monitoring of expression levels of thousands of genes simultaneously. In microarray data analysis, the comparison of gene-expression profiles with respect to different conditions and the selection of biologically interesting...

Two different estimation techniques for the spectrum of a nonstationary time series are compared empirically. Both of them are assuming a time-dependent autoregressive (AR-) model for the data. The first estimation technique used is the Frequency State Dependent Model (FSDM-) technique (Schmitz...

In this paper, we have presented the second level nesting of Bonney's disposition model (Bonney, 1998) and examined the implications of higher level nesting of the disposition model in relation to the dimension of the parameter space. We have also compared the performance of the disposition...