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Management of Community-Acquired Pneumonia: Defining the Role of Azithromycin

Gunasekara, Nishan S.; Barman Balfour, Julia A. - In: Disease Management and Health Outcomes 5 (1999) 1, pp. 41-54

lower incidence of gastrointestinal adverse events than erythromycin. Azithromycin is also associated with fewer … emphasis on the use of the macrolides. Azithromycin, the prototype azalide, is a macrolide derivative with a broad … antimicrobial spectrum including enhanced activity against Haemophilus influenzae relative to erythromycin. Its distinctive …

Persistent link: https://www.econbiz.de/10005590122

The Clinical and Economic Potential of Cyclosporin Drug Interactions

Martin, Jill E.; Daoud, A. Jamal; Schroeder, Timothy J.; … - In: PharmacoEconomics 15 (1999) 4, pp. 317-337

blockers, diltiazem, verapamil and nicardipine; and the macrolide antibacterials, erythromycin and related compounds. Although …

Persistent link: https://www.econbiz.de/10005449102

Cost Effectiveness of Prophylaxis for Opportunistic Infections in AIDS: An Overview and Methodological Discussion

Freedberg, Kenneth A.; Paltiel, A. David - In: PharmacoEconomics 14 (1998) 2, pp. 165-174

Dramatic progress has recently been made in defining the pathogenesis and treatment of HIV infection. For the first time in the history of the AIDS epidemic, clinicians have at their disposal an understanding of the replication kinetics of HIV, reliable assays to measure viral load, an...

Persistent link: https://www.econbiz.de/10005449227

Economic Evaluation of Antibacterials in the Treatment of Acute Sinusitis

Laurier, Claudine; Lachaine, Jean; Ducharme, Murray - In: PharmacoEconomics 15 (1999) 1, pp. 97-113

. Interventions: The antibacterials studied were amoxicillin, amoxicillin/clavulanate, azithromycin, cefaclor, cefuroxime axetil and … costs when compared with the other antibacterials. Low dosages of clarithromycin and azithromycin followed amoxicillin in … sinusitis, with low dose clarithromycin and azithromycin as second choices. …

Persistent link: https://www.econbiz.de/10004990334

Outpatient Parenteral Antibacterial Therapy of Serious Infections: The Role of Ceftriaxone

Barman Balfour, Julia A.; Lamb, Harriet M. - In: Disease Management and Health Outcomes 4 (1998) 4, pp. 225-236

Outpatient parenteral antibacterial therapy (OPAT) is an increasingly popular means of containing the costs of antibacterial therapy, by avoiding the need for hospitalisation or allowing early discharge from hospital, in patients with serious infections. It also offers increased comfort and...

Persistent link: https://www.econbiz.de/10004990310

Principles of Perioperative Antibacterial Prophylaxis: Management of Surgical Site Infections

Bohnen, John - In: Disease Management and Health Outcomes 6 (1999) 2, pp. 73-81

This article reviews perioperative antibacterial prophylaxis, a discrete in-hospital intervention that prevents surgical site infections and reduces the costs of complications and adverse effects of care. Clinical trials have shown that, when used appropriately, prophylactic antibacterial agents...

Persistent link: https://www.econbiz.de/10005448844

Management of Tuberculosis: Special Considerations

Choi, Chester - In: Disease Management and Health Outcomes 4 (1998) 4, pp. 205-216

The treatment and prevention of tuberculosis have gained importance as the number of cases continues to increase worldwide and the ability of the disease to pass from one area to another becomes progressively greater. Interventions used in the US to help control the disease include the...

Persistent link: https://www.econbiz.de/10005448913

Management of Community-Acquired Pneumonia: The Role of Clarithromycin

Barman Balfour, Julia A.; Lamb, Harriet M. - In: Disease Management and Health Outcomes 6 (1999) 4, pp. 225-239

Legionella spp. Clarithromycin has similar efficacy to erythromycin in adults and children with mild to moderate CAP but is … encourage patient compliance. As with erythromycin, clarithromycin interacts with a wide range of drugs metabolised by the CYP … advantages over erythromycin, so all factors should be considered when selecting such an agent for treatment. Although …

Persistent link: https://www.econbiz.de/10005448917

Management of Febrile Episodes in Neutropenic Patients: Defining the Role of Meropenem

Lamb, Harriet M.; Goa, Karen L. - In: Disease Management and Health Outcomes 5 (1999) 2, pp. 101-115

Neutropenic patients with cancer are at risk of serious infection, particularly if neutropenia is severe or prolonged. Because patients with neutropenia have a diminished inflammatory response, fever is sometimes the first, and only, sign of infection. Prompt empirical antibacterial therapy is...

Persistent link: https://www.econbiz.de/10005448947

Counting the Costs of Drug-Related Adverse Events

White, T. Jeffrey; Arakelian, Annet; Rho, Jay P. - In: PharmacoEconomics 15 (1999) 5, pp. 445-458

Adverse drug events occur frequently and lead to a significant number of fatalities each year. It has been estimated that fatalities directly attributable to adverse drug reactions are the fourth to sixth leading cause of death in US hospitals, exceeding deaths caused by pneumonia and diabetes....

Persistent link: https://www.econbiz.de/10005449050

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