the treatment of seizures associated with Lennox-Gastaut syndrome (LGS) in patients aged ≥4 years. The efficacy of oral … horizon of 3 years, assessed the cost effectiveness and cost utility, respectively, of rufinamide compared with topiramate and … lamotrigine as adjunctive therapy in patients with LGS from the perspective of the UK NHS. The cost-effectiveness analysis …

effectiveness, as well as therapeutic value and budget impact. Since 1 January 2005, drug manufacturers are formally required to … substantiate the cost effectiveness of drugs that have therapeutic added value in comparison with existing ones through … costs and effects were correct. However, drug indication, form (i.e. cost utility/cost effectiveness) and time horizon of …

incremental cost effectiveness of anticoagulants in patients with ACS. Abstract: Methods:Methods: Studies were identified using … specialist databases (UK NHS Economic Evaluation Database [NHS EED] and Cost-Effectiveness Analysis &lsqb … supportive randomized trials and the possible underestimation of bleeding costs. The effectiveness and safety of bivalirudin, a …

demonstrated its efficacy in bipolar I and II disorders, and the drug has been generally well tolerated in clinical trials. Three … cost-effectiveness analyses of maintenance therapy in bipolar I disorder, which used similar Markov models and incorporated … US. Quetiapine either dominated comparators (typically mood stabilizers alone) or was associated with incremental cost-effectiveness …

significantly more effective than warfarin for this endpoint, as well as most other efficacy endpoints. The incidence of major … systemic embolism in AF patients, as the results were below generally accepted cost-effectiveness thresholds. In contrast, the … incremental cost per QALY gained for dabigatran 110 mg twice daily versus warfarin exceeded cost-effectiveness thresholds in all …