Similar Search Results

Dynamic fitness landscapes: expansions for small mutation rates

Wilke, Claus O.; Ronnewinkel, Christopher - In: Physica A: Statistical Mechanics and its Applications 290 (2001) 3, pp. 475-490

We study the evolution of asexual microorganisms with small mutation rate in fluctuating environments, and develop techniques that allow us to expand the formal solution of the evolution equations to first order in the mutation rate. Our method can be applied to both discrete time and continuous...

Persistent link: https://www.econbiz.de/10010872872

Optimal adaptive performance and delocalization in NK fitness landscapes

Campos, Paulo R.A; Adami, Christoph; Wilke, Claus O - In: Physica A: Statistical Mechanics and its Applications 304 (2002) 3, pp. 495-506

We investigate the evolutionary dynamics of a finite population of sequences adapting to NK fitness landscapes. We find that, unlike in the case of an infinite population, the average fitness in a finite population is maximized at a small but finite, rather than vanishing, mutation rate. The...

Persistent link: https://www.econbiz.de/10010872601

Punctuated evolution for the quasispecies model

Krug, Joachim; Karl, Christian - In: Physica A: Statistical Mechanics and its Applications 318 (2003) 1, pp. 137-143

Biological evolution in a sequence space with random fitnesses is studied within Eigen's quasispecies model. A strong …

Persistent link: https://www.econbiz.de/10011057110

Modeling viral coevolution: HIV multi-clonal persistence and competition dynamics

Bagnoli, F.; Liò, P.; Sguanci, L. - In: Physica A: Statistical Mechanics and its Applications 366 (2006) C, pp. 333-346

The coexistence of different viral strains (quasispecies) within the same host are nowadays observed for a growing … not yet been understood. We present a model of HIV quasispecies competition, which describes the conditions of viral … quasispecies coexistence under different immune system conditions. Our model incorporates both T and B cells responses, and we show …

Persistent link: https://www.econbiz.de/10011058645

A linear algebra model for quasispecies

Garcı́a-Pelayo, Ricardo - In: Physica A: Statistical Mechanics and its Applications 309 (2002) 1, pp. 131-156

In the present work we present a simple model of the population genetics of quasispecies. We show that the error … in terms of its abundance in the quasispecies, a formula for the stable distribution of a quasispecies in which the … stable quasispecies (such as in the infection by a virus) and the fitness of quasispecies. …

Persistent link: https://www.econbiz.de/10011063551