Adaptive clinical trials for new drugs or treatment options promise significant benefits to both trial sponsors and patients, but complicate resource allocation. We study the patient enrollment and trial termination decision in a Phase 3 group sequential adaptive trial, which allows for early...

Background: Antibiotics have been overprescribed to treat infectious diseases and have generated antimicrobial resistances that reduce their effectiveness. Following the rationale behind the new paradigm of personalized medicine, point-of-care diagnostic testing (POCT) has been proposed to...

Vaccine effectiveness for COVID-19 is typically estimated for different outcomes that often are hierarchical in severity (e.g. any documented infection, symptomatic infection, hospitalization, death) and which may be subsets of each other. Conditional effectiveness for a more severe outcome...