We address the problem of maximally selected chi-square statistics in the case of a binary Y variable and a nominal X variable with several categories. The distribution of the maximally selected chi-square statistic has already been derived when the best cutpoint is chosen from a continuous or...

Partial Least Squares (PLS) is a highly efficient statistical regression technique that is well suited for the analysis of high-dimensional genomic data. In this paper we review the theory and applications of PLS both under methodological and biological points of view. Focusing on microarray...

We propose a novel method to model nonlinear regression problems by adapting the principle of penalization to Partial Least Squares (PLS). Starting with a generalized additive model, we expand the additive component of each variable in terms of a generous amount of B-Splines basis functions. In...