This dissertation consists of five independent projects. In each project, a novelstatistical method was developed to address a practical problem encountered in genomiccontexts. For example, we considered testing for constant nonparametric effectsin a general semiparametric regression model in...

In parametric regression problems, estimation of the parameter of interest is typically achieved via the solution of a set of unbiased estimating equations. We are interested in problems where in addition to this parameter, the estimating equations consist of an unknown nuisance function which...

In parametric regression problems, estimation of the parameter of interest is typically achieved via the solution of a set of unbiased estimating equations. We are interested in problems where in addition to this parameter, the estimating equations consist of an unknown nuisance function which...