As I document using evidence from a journal data repository that I manage, the datasets used in empirical work are getting larger. When we use very large datasets, it can be dangerous to rely on standard methods for statistical inference. In addition, we need to worry about computational issues....

The fundamental problem of external validity is not to generalize from one experiment, so much as to experimentally test generalizable theories. That is, theories that explain the systematic variation of causal effects across contexts. Here we show how the graphical language of causal diagrams...