In practice, simulation analysts often change only one factor at a time, and use graphical analysis of the resulting Input/Output (I/O) data. Statistical theory proves that more information is obtained when applying Design Of Experiments (DOE) and linear regression analysis. Unfortunately,...

This note reconciles existing evidence on the abilities of the bootstrap with its use in the cost-effectiveness literature. We emphasise the role played by pivotal statistics to explain the ability of the bootstrap to provide asymptotic refinements for the Incremental Net Benefit statistic. The...

This chapter surveys two methods for the optimization of real-world systems that are modelled through simulation. These methods use either linear regression metamodels, or Kriging (Gaussian processes). The metamodel type guides the design of the experiment; this design fixes the input...

Optimization of simulated systems is the goal of many methods, but most methods assume known environments. We, however, develop a `robust' methodology that accounts for uncertain environments. Our methodology uses Taguchi's view of the uncertain world, but replaces his statistical techniques by...

Efficient Global Optimization (EGO) is a popular method that searches sequentially for the global optimum of a simulated system. EGO treats the simulation model as a black-box, and balances local and global searches. In deterministic simulation, EGO uses ordinary Kriging (OK), which is a special...

Optimization of simulated systems is tackled by many methods, but most methods assume known environments. This article, however, develops a 'robust' methodology for uncertain environments. This methodology uses Taguchi's view of the uncertain world, but replaces his statistical techniques by...