Background: Concerns about rising health care costs require rigorous economic study to inform clinical and policy decision-making. Micro-costing is a cost estimation methodology employing detailed resource utilization and unit cost data to generate precise estimates of economic costs....

This open access book proposes a conceptual framework for understanding measurement across a broad range of scientific fields and areas of application, such as physics, engineering, education, and psychology. It addresses contemporary issues and controversies within measurement in light of the...

Safety-first portfolio optimization is concerned with maximizing the expected portfolio return subject to a safety-first constraint, which is defined as the probability of failing to achieve a specified target. Commonly the target is assumed to be fixed, which, however, leads to significant...

This paper analyzes the safety-first portfolio model under two different target assumptions, the fixed target, which is commonly assumed in the literature, and the random target, which has played only a minor role so far. As both targets can be easily motivated, the open question is, which...