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Nonparametric methods for analyzing replication origins in genomewide data

Ghosh, Debashis - Berkeley Electronic Press - 2004

Due to the advent of high-throughput genomic technology, it has become possible to globally monitor cellular activities on a genomewide basis. With these new methods, scientists can begin to address important biological questions. One such question involves the identification of replication...

Persistent link: https://www.econbiz.de/10005246062

Visualisation of Gene Expression Data Ã¢ÂÂ the GE-biplot, the Chip-plot and the Gene-plot

Pittelkow, Yvonne; Wilson, Susan - In: Statistical Applications in Genetics and Molecular Biology 2 (2007) 1, pp. 6-6

Visualisation methods for exploring microarray data are particularly important for gaining insight into data from gene …. Further, good visualisation techniques are useful for outlier detection in microarray data and for aiding biological … display of microarray data as both the genes and the chips can be simultaneously plotted. In this paper we describe several …

Persistent link: https://www.econbiz.de/10005046577

Early Diagnostic Marker Panel Determination for Microarray Based Clinical Studies

Jaeger, Jochen; Weichenhan, Dieter; Ivandic, Boris; … - In: Statistical Applications in Genetics and Molecular Biology 4 (2007) 1, pp. 9-9

We present a novel, cost efficient two-phase design for predictive clinical gene expression studies: early marker panel determination (EMPD). In Phase-1, genome-wide microarrays are used only for a small number of individual patient samples. From this Phase-1 data a panel of marker genes is...

Persistent link: https://www.econbiz.de/10005046621

Statistical Significance Threshold Criteria For Analysis of Microarray Gene Expression Data

Cheng, Cheng; Pounds, Stanley; Boyett, James; Pei, Deqing; … - In: Statistical Applications in Genetics and Molecular Biology 3 (2007) 1, pp. 36-36

The methodological advancement in microarray data analysis on the basis of false discovery rate (FDR) control, such as …

Persistent link: https://www.econbiz.de/10005752555

Orthology-Based Multilevel Modeling of Differentially Expressed Mouse and Human Gene Pairs

Ogorek, Benjamin; Stefanski, Leonard - In: Statistical Applications in Genetics and Molecular Biology 8 (2009) 1, pp. 2-2

There is great interest in finding human genes expressed through pharmaceutical intervention, thus opening a genomic window into benefit and side-effect profiles of a drug. Human insight gained from FDA-required animal experiments has historically been limited, but in the case of gene expression...

Persistent link: https://www.econbiz.de/10005585054

Calculating the Statistical Significance of Changes in Pathway Activity From Gene Expression Data

JÃÂ¶rg RahnenfÃÂ¼hrer; Domingues, Francisco; … - In: Statistical Applications in Genetics and Molecular Biology 3 (2007) 1, pp. 16-16

findings from microarray experiments.Recently introduced methods test if members of predefined gene sets are enriched in a list … of top-ranked genes in a microarray study. We improve this approach by defining scores that depend on all members of the …

Persistent link: https://www.econbiz.de/10005585090

Transcriptional modulation of the developing immune system by early life social adversity

Cole, Steven W.; Conti, Gabriella; Arevalo, Jesusa M.; … - 2012

To identify molecular mechanisms by which early life social conditions might influence adult risk of disease in rhesus macaques (Macaca mulatta), we analyze changes in basal leukocyte gene expression profiles in 4-month-old animals reared under adverse social conditions. Compared to the basal...

Persistent link: https://www.econbiz.de/10010289875

Modelling and trading the London, New York and Frankfurt stock exchanges with a new gene expression programming trader tool

Karathanasopoulos, Andreas - In: Intelligent systems in accounting finance and … 24 (2017) 1, pp. 3-11

Persistent link: https://www.econbiz.de/10011757253

Transcriptional Modulation of the Developing Immune System by Early Life Social Adversity

Cole, Steven W.; Conti, Gabriella; Arevalo, Jesusa M.; … - Institute for the Study of Labor (IZA) - 2012

Persistent link: https://www.econbiz.de/10010990923

Experimental Design for Two-Color Microarrays Applied in a Pre-Existing Split-Plot Experiment

Milliken, G.; Garrett, K.; Travers, S. - In: Statistical Applications in Genetics and Molecular Biology 6 (2007) 1, pp. 20-20

Microarray applications for the study of gene expression are becoming accessible for researchers in more and more … microarray within a level of the subplot treatment. Design B has crossed levels paired on the same microarray. Design C has … levels of the treatment applied to subplots paired on the same microarray within a whole plot. Designs A and B have lower …

Persistent link: https://www.econbiz.de/10005246492