The prediction of the complete matrix of base pairing probabilities was applied to the 3' non-coding region (NCR) of flavivirus genomes. This approach identifies not only well-defined secondary structure elements but also regions of high structural flexibility. Flaviviruses, many of which are...

During the development of a multicellular organism for a zygote, a large number of epigenetic interactions take place on every level of suborganismal organization. This raises the possibility that the system of epigenetic interactions may compensate or ÒbufferÓ some of the changes that occur...

To delineate the astronomical number of possible interactions of all genes in a genome is a task for which conventional experimental techniques are ill suited. Sorely needed are rapid and inexpensive methods that identify candidates for interacting genes, candidates that can be further...

The critical boundaries separating ordered from chaotic behavior in randomly wired S-state networks are calculated. These networks are a natural generalization of random Boolean net and are proposed as an extended approach to genetic regulatory systems, sets of cells in different states or...