Dette, Holger; Trampisch, Matthias; Hothorn, Ludwig A. - Institut für Wirtschafts- und Sozialstatistik, … - 2007
In this paper, we describe an adjusted method to facilitate a non-inferiority trial by a three-arm robust design. Because local optimal designs derived in Hasler et al. [2007] require knowledge about the ratios of the population variances and are not necessarily robust with respect to possible...