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Microarray applications for the study of gene expression are becoming accessible for researchers in more and more systems. Applications from field or laboratory experiments are often complicated by the need to superimpose sample pairing for two-color arrays on experimental designs that may...
Persistent link: https://www.econbiz.de/10005246492
Stochastic dependence between gene expression levels in microarray data is of critical importance for the methods of statistical inference that resort to pooling test statistics across genes. The empirical Bayes methodology in the nonparametric and parametric formulations, as well as closely...
Persistent link: https://www.econbiz.de/10005752557
Modern methods of microarray data analysis are biased towards selecting those genes that display the most pronounced differential expression. The magnitude of differential expression does not necessarily indicate biological significance and other criteria are needed to supplement the information...
Persistent link: https://www.econbiz.de/10005752564
One of the prevailing ideas in the literature on microarray data analysis is to pool the expression measures across genes and treat them as a sample drawn from some distribution. Several universal laws were proposed to analytically describe this distribution. This idea raises a number of...
Persistent link: https://www.econbiz.de/10005585102