Some of the methods of estimation of allele frequencies and inbreeding coefficients in a K-allele model are examined. A result that has long been assumed to be true is proved. That is, in the presence of inbreeding, the maximum likelihood estimators of the allele frequencies and of the...

In the past decade, many statistical methods have been proposed for the analysis of case-control genetic data with an emphasis on haplotype-based disease association studies. Most of the methodology has concentrated on the estimation of genetic (haplotype) main effects. Most methods accounted...

Consider a probability model P θ,α , where θ=(θ 1 ,θ 2 ,…,θ k ) T is a parameter vector of interest, and α is some nuisance parameter. The problem of testing null hypothesis H 0 : θ 1 =θ 2 =…=θ k against selecting one of k alternative hypotheses H i :θ i =θ [ k ] θ [1] , i...

Abstract For many decades, statisticians have made attempts to prepare the Bayesian omelette without breaking the Bayesian eggs; that is, to obtain probabilistic likelihood-based inferences without relying on informative prior distributions. A recent example is Murray Aitkin´s recent book,...

This paper is concerned with simulation-based inference in generalized models of stochastic volatility defined by heavy-tailed Student-t distributions (with unknown degrees of freedom) and exogenous variables in the observation and volatility equations and a jump component in the observation...

This paper studies efficient market hypothesis in prediction markets and the results are illustrated for the in-play football betting market using the quoted odds for the English Premier League. Our analysis is based on the martingale property, where the last quoted probability should be the...