This dissertation includes three components. Component 1 provides an estima-tion procedure for circadian parameters in cyanobacteria. Component 2 explores therelationship between baseline and amplitude by model selection under the frameworkof smoothing spline. Component 3 investigates properties...

Semiparametric models play important roles in the field of biological statistics. In this dissertation, two types of semiparametic models are to be studied. One is the partially linear model, where the parametric part is a linear function. We are to investigate the two common estimation methods...

Functional data analysis (FDA) is an active field of statistics, in which the primary subjectsin the study are curves. My dissertation consists of two innovative applications offunctional data analysis in biology. The data that motivated the research broadened thescope of FDA and demanded new...

This dissertation consists of five independent projects. In each project, a novelstatistical method was developed to address a practical problem encountered in genomiccontexts. For example, we considered testing for constant nonparametric effectsin a general semiparametric regression model in...

Semiparametric regression has become very popular in the field of Statistics over theyears. While on one hand more and more sophisticated models are being developed,on the other hand the resulting theory and estimation process has become more andmore involved. The main problems that are...