In many fields of applications, test statistics are obtained by combining estimates from several experiments, studies or centres of a multicentre trial. The commonly used test procedure to judge the evidence of a common overall effect can result in a considerable overestimation of the...

In combining several tests of significance the individual test statistics are allowed to be dependent. By choosing the weighted inverse normal method for the combination, the dependency of the original test statistics is then characterized by a correlation of the transformed statistics. For this...

Sind in einer statistischen Analyse mehr als eine Variationsursache zu berücksichtigen_ so zerfällt die Gesamtvariation in mehrere Komponenten. Für diese sind in der Regel auch Beziehungen oder Ordnungen bekannt. Aber keine der bekannten Schätztheorien ist in der Lage, diese Ordnungen auch...

In a general variance component model with positive variance components a short-cut method is presented that yields almost everywhere for these components positive estimators that are invariant with respect to mean value translation and stay near the unbiasedness.

A class of self-designing clinical trials is considered which according to an effective but simple, finite learning algorithm consists of automatically adaptively planned weighted group sequential trials with a decision about rejection of the null-hypothesis at each step, but the full...

In this paper we derive asymptotic x2-tests for general linear hypotheses on variance components using repeated variance components models. In two examples, the two-way nested classification model and the two-way crossed classification model with interaction, we explicitly investigate the...

Research in combining of economic forecasts made by several research institutes on the same economic variable has focused on estimation, hoping that the combined forecast will be improved by taking into account the expert opinions of the institutes. We provide a confidence interval on the...

Background: There are already many effective topical therapies available for use in the treatment of chronic plaque psoriasis. Unfortunately, these treatments are often associated with a not insignificant risk of undesirable effects. Objective and methods: In the randomized, prospective clinical...