his paper reconsiders sequential Monte Carlo approaches to Bayesian inference in the light of massively parallel desktop computing capabilities now well within the reach of individual academics. It first develops an algorithm that is well suited to parallel computing in general and for which...

To economically evaluate a new drug or other medical innovation one must assess both the changes in costs and in benefits. Safety and efficacy matter, but so do resource costs and social benefits. This paper evaluates the effects on expenditures of the recent introduction of cimetidine, a drug...