We consider a dose-finding trial in phase IIB of drug development. For choosing an appropriate design for this trial the specification of two points is critical: an appropriate model for describing the dose-effect relationship and the specification of the aims of the trial (objectives), which...

We consider a dose-finding trial in phase IIB of drug development. For choosing an appropriate design for this trial the specification of two points is critical: an appropriate model for describing the dose-effect relationship and the specification of the aims of the trial (objectives), which...

A main objective in clinical trials is to find the best treatment in a given finite class of competing treatments and then to show superiority of this treatment against a control treatment. The traditional procedure estimates the best treatment in a first trial. Then in an independent second...

Given a Brownian bridge B0 with trend g:[0,1]--[0,[infinity]), Y(z)=g(z)+B0(z),z[set membership, variant][0,1],we are interested in testing H0:g[reverse not equivalent]0 against the alternative K:g0. For this test problem we study weighted Kolmogorov testswhere c0 is a suitable constant and...

To check regression models Bischoff and Miller (2006a. Optimal designs which are efficient for lack of fit tests. Ann. Stat., to appear.) introduced optimal designs to estimate a parameter in the class of designs which guarantee a certain efficiency with respect to the power of a lack of fit...