To check regression models Bischoff and Miller (2006a. Optimal designs which are efficient for lack of fit tests. Ann. Stat., to appear.) introduced optimal designs to estimate a parameter in the class of designs which guarantee a certain efficiency with respect to the power of a lack of fit...

A main objective in clinical trials is to find the best treatment in a given finite class of competing treatments and then to show superiority of this treatment against a control treatment. The traditional procedure estimates the best treatment in a first trial. Then in an independent second...