Hashem, I.; Telen, D.; Nimmegeers, P.; van Impe, Jan … - 2022
Networks constrain the evolution of their parts. In living cells, any mutation in the metabolic network responsible for … be present at the same time to shift a network to a higher fitness state, yet any of them occurring individually can … deteriorate the fitness of the overall network, then this improved state will largely remain inaccessible. In this paper, we …