Training a support vector machine SVM leads to a quadratic optimization problem with bound constraints and one linear equality constraint. Despite the fact that this type of problem is well understood, there are many issues to be considered in designing an SVM learner. In particular, for large...

The minimum number of misclassifications achievable with affine hyper_ planes on a given set of labeled points is a key quantity in both statistics and computational learning theory. However, determining this quantity exactly is essentially NP_hard_ cf_ Höfgen, Simon and van Horn (1995.) Hence,...

The paper describes a case study in combining different methods for acquiring medical knowledge. Given a huge amount of noisy, high dimensional numerical time series data describing patients in intensive care, the support vector machine is used to learn when and how to change the dose of which...

Training a support vector machine SVM leads to a quadratic optimization problem with bound constraints and one linear equality constraint. Despite the fact that this type of problem is well understood, there are many issues to be considered in designing an SVM learner. In particular, for large...

Operational protocols are a valuable means for quality control. However, developing operational protocols is a highly complex and costly task. We present an integrated approach involving both intelligent data analysis and knowledge acquisition from experts that supports the development of...

Operational protocols are a valuable means for quality control. However, developing operational protocols is a highly complex and costly task. We present an integrated approach involving both intelligent data analysis and knowledge acquisition from experts that supports the development of...

The paper describes a case study in combining different methods for acquiring medical knowledge. Given a huge amount of noisy, high dimensional numerical time series data describing patients in intensive care, the support vector machine is used to learn when and how to change the dose of which...