A multi-modal search space can be defined as having multiple attraction basins – each basin has a single local optimum which is reached from all points in that basin when greedy local search is used. Optimization in multi-modal search spaces can then be viewed as a two-phase process. The first...

Computer modeling of protein-ligand interactions is one of the most important phases in a drug design process. Part of the process involves the optimization of highly multi-modal objective (scoring) functions. This research presents the Minimum Population Search heuristic as an alternative for...

Spanish abstract. El cómputo de alto rendimiento es una necesidad para el desarrollo de investigaciones con grandes volúmenes de datos. La creciente demanda de este tipo de resultados ha impulsado a varios centros de investigación a poner en funcionamiento recursos de cómputo de alto...

Computer modeling of protein-ligand interactions is one of the most important phases in a drug design process. Part of the process involves the optimization of highly multi-modal objective (scoring) functions. This research presents the Minimum Population Search heuristic as an alternative for...

As Internet retailers move into mainstream markets and traditional retailers venture onto the Internet, an increasingly important management question is how to successfully combine 'real' and 'virtual' operations. This paper aims to highlight some of the key management issues and critical...